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Scrapie prion protein accumulation by scrapie-infected neuroblastoma cells abrogated by exposure to a prion protein antibody

Exposure of susceptible neuroblastoma N2a cells to mouse scrapie prions leads to infection, as evidenced by the continued presence of the scrapie form of the prion protein (PrP(Sc)) and infectivity after 300 or more cell doublings. We find that exposure to phosphatidylinositol-specific phospholipase...

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Detalhes bibliográficos
Main Authors: Enari, Masato, Flechsig, Eckhard, Weissmann, Charles
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 2001
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC55414/
https://ncbi.nlm.nih.gov/pubmed/11470893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.151242598
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