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Islet Amyloid Polypeptide Membrane Interactions: Effects of Membrane Composition

Amyloid formation by islet amyloid polypeptide (IAPP) contributes to β-cell dysfunction in type-2 diabetes. Perturbation of the β-cell membrane may contribute to IAPP induced toxicity. We examine the effects of lipid composition, salt and buffer on IAPP amyloid formation and on the ability of IAPP t...

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Bibliografiska uppgifter
I publikationen:Biochemistry
Huvudupphovsmän: Zhang, Xiaoxue, St. Clair, Johnna R., London, Erwin, Raleigh, Daniel P.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5541234/
https://ncbi.nlm.nih.gov/pubmed/28054763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b01016
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