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Biomarker Accessible and Chemically Addressable Mechanistic Subtypes of BRAF Melanoma

Genomic diversity among melanoma tumors limits durable control with conventional and targeted therapies. Nevertheless, pathological activation of the ERK1/2 pathway is a linchpin tumorigenic mechanism associated with the majority of primary and recurrent disease. Therefore, we sought to identify the...

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發表在:Cancer Discov
Main Authors: Eskiocak, Banu, McMillan, Elizabeth A., Mendiratta, Saurabh, Kollipara, Rahul K., Zhang, Hailei, Humphries, Caroline G., Wang, Changguang, Garcia-Rodriguez, Jose, Ding, Ming, Zaman, Aubhishek, Rosales, Tracy I., Eskiocak, Ugur, Smith, Michael, Sudderth, Jessica, Komurov, Kakajan, Deberardinis, Ralph, Wellbrock, Claudia, Davies, Michael A., Wargo, Jennifer A., Yu, Yonghao, De Brabander, Jef K., Williams, Noelle S., Chin, Lynda, Rizos, Helen, Long, Georgina, Kittler, Ralf, White, Michael A.
格式: Artigo
語言:Inglês
出版: 2017
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5540806/
https://ncbi.nlm.nih.gov/pubmed/28455392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-16-0955
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