Arl13b promotes gastric tumorigenesis by regulating Smo trafficking and activation of the Hedgehog signaling pathway

Inhibitors of the Hedgehog (Hh) pathway transducer Smoothened (Smo) have been approved for cancer treatment, but Smo mutations often lead to tumor resistance and it remains unclear how Smo is regulated. In this study, we identified the small GTPase Arl13b as a novel partner and regulator of Smo. Arl...

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Gepubliceerd in:Cancer Res
Hoofdauteurs: Shao, Jia, Xu, Linlin, Chen, Limin, Lu, Quqin, Xie, Xinsheng, Shi, Wei, Xiong, Huanting, Shi, Chao, Huang, Xuan, Mei, Jinhong, Rao, Hai, Lu, Hua, Lu, Nonghua, Luo, Shiwen
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5540784/
https://ncbi.nlm.nih.gov/pubmed/28611043
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-16-2461
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