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SPOP suppresses tumorigenesis by regulating Hedgehog/Gli2 signaling pathway in gastric cancer
BACKGROUND: Recent evidence suggests that aberrant activation of Hedgehog (Hh) signaling by Gli transcription factors is characteristic of a variety of aggressive human carcinomas including gastric cancer. Speckle-type POZ protein, SPOP, is an E3 ubiquitin ligase adaptor, and it is found to inhibit...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4172815/ https://ncbi.nlm.nih.gov/pubmed/25204354 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-014-0075-8 |
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