SPOP suppresses tumorigenesis by regulating Hedgehog/Gli2 signaling pathway in gastric cancer

BACKGROUND: Recent evidence suggests that aberrant activation of Hedgehog (Hh) signaling by Gli transcription factors is characteristic of a variety of aggressive human carcinomas including gastric cancer. Speckle-type POZ protein, SPOP, is an E3 ubiquitin ligase adaptor, and it is found to inhibit...

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Hauptverfasser: Zeng, Chunyan, Wang, Yao, Lu, Quqin, Chen, Jiang, Zhang, Junyan, Liu, Tao, Lv, Nonghua, Luo, Shiwen
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2014
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4172815/
https://ncbi.nlm.nih.gov/pubmed/25204354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-014-0075-8
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