Chemical Genetic Discovery of PARP Targets Reveals a Role for PARP-1 in Transcription Elongation

Poly(ADP-ribose) polymerases (PARPs) are a family of enzymes that modulate diverse biological processes through covalent transfer of ADP-ribose from NAD(+) onto substrate proteins. Here, we report a robust NAD(+) analog-sensitive approach for PARPs, which allows PARP-specific ADP-ribosylation of sub...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Science
Prif Awduron: Gibson, Bryan A., Zhang, Yajie, Jiang, Hong, Hussey, Kristine M., Shrimp, Jonathan H., Lin, Hening, Schwede, Frank, Yu, Yonghao, Kraus, W. Lee
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5540732/
https://ncbi.nlm.nih.gov/pubmed/27256882
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaf7865
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