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Identification of Protein Substrates of Specific PARP Enzymes Using Analog-Sensitive PARP Mutants and a ‘Clickable’ NAD(+) Analog

The PARP family of ADP-ribosyl transferases contains 17 members in human cells, most of which catalyze the transfer of the ADP-ribose moiety of NAD(+) onto their target proteins. This post-translational modification plays important roles in cellular signaling, especially during cellular stresses, su...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Methods Mol Biol
Hauptverfasser: Gibson, Bryan A., Kraus, W. Lee
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6465536/
https://ncbi.nlm.nih.gov/pubmed/28695507
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-4939-6993-7_9
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