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Pharmacoperone rescue of vasopressin 2 receptor mutants reveals unexpected constitutive activity and coupling bias

Pharmacoperones are small molecules that diffuse into cells and rescue misfolded, mistrafficked protein mutants, restoring their function. These substances act with high target specificity, serving as templates to fold (or refold) receptors, enzymes, ion channels or other proteins and enable them to...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Janovick, Jo Ann, Spicer, Timothy P., Bannister, Thomas D., Scampavia, Louis, Conn, P. Michael
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5540481/
https://ncbi.nlm.nih.gov/pubmed/28767678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0181830
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