N-Myc induces an EZH2-mediated transcriptional program driving Neuroendocrine Prostate Cancer

The transition from castration resistant prostate adenocarcinoma (CRPC) to neuroendocrine prostate cancer (NEPC) has emerged as an important mechanism of treatment resistance. NEPC is associated with over-expression and gene amplification of MYCN (encoding N-Myc). N-Myc is an established oncogene in...

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Udgivet i:Cancer Cell
Main Authors: Dardenne, Etienne, Beltran, Himisha, Benelli, Matteo, Gayvert, Kaitlyn, Berger, Adeline, Puca, Loredana, Cyrta, Joanna, Sboner, Andrea, Noorzad, Zohal, MacDonald, Theresa, Cheung, Cynthia, Yuen, Ka Shing, Gao, Dong, Chen, Yu, Eilers, Martin, Mosquera, Juan-Miguel, Robinson, Brian D., Elemento, Olivier, Rubin, Mark A., Demichelis, Francesca, Rickman, David S.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5540451/
https://ncbi.nlm.nih.gov/pubmed/27728805
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2016.09.005
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