Divergent clonal evolution of castration resistant neuroendocrine prostate cancer

An increasingly recognized resistance mechanism to androgen receptor (AR)-directed therapy in prostate cancer involves epithelial plasticity, wherein tumor cells demonstrate low to absent AR expression and often neuroendocrine features. The etiology and molecular basis for these “alternative” treatm...

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Publicado en:Nat Med
Autores principales: Beltran, Himisha, Prandi, Davide, Mosquera, Juan Miguel, Benelli, Matteo, Puca, Loredana, Cyrta, Joanna, Marotz, Clarisse, Giannopoulou, Eugenia, Chakravarthi, Balabhadrapatruni V.S.K., Varambally, Sooryanarayana, Tomlins, Scott A., Nanus, David M., Tagawa, Scott T., Van Allen, Eliezer M., Elemento, Olivier, Sboner, Andrea, Garraway, Levi A., Rubin, Mark A., Demichelis, Francesca
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4777652/
https://ncbi.nlm.nih.gov/pubmed/26855148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4045
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