Divergent clonal evolution of castration resistant neuroendocrine prostate cancer

An increasingly recognized resistance mechanism to androgen receptor (AR)-directed therapy in prostate cancer involves epithelial plasticity, wherein tumor cells demonstrate low to absent AR expression and often neuroendocrine features. The etiology and molecular basis for these “alternative” treatm...

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Bibliografiske detaljer
Udgivet i:Nat Med
Main Authors: Beltran, Himisha, Prandi, Davide, Mosquera, Juan Miguel, Benelli, Matteo, Puca, Loredana, Cyrta, Joanna, Marotz, Clarisse, Giannopoulou, Eugenia, Chakravarthi, Balabhadrapatruni V.S.K., Varambally, Sooryanarayana, Tomlins, Scott A., Nanus, David M., Tagawa, Scott T., Van Allen, Eliezer M., Elemento, Olivier, Sboner, Andrea, Garraway, Levi A., Rubin, Mark A., Demichelis, Francesca
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4777652/
https://ncbi.nlm.nih.gov/pubmed/26855148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nm.4045
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