Engineering humanized antibody framework sequences for optimal site-specific conjugation of cytotoxins

The prevailing techniques used to generate antibody-drug conjugates (ADCs) involve random conjugation of the linker-drug to multiple lysines or cysteines in the antibody. Engineering natural and non-natural amino acids into an antibody has been demonstrated to be an effective strategy to produce hom...

Descripción completa

Guardado en:
Detalles Bibliográficos
Publicado en:MAbs
Autores principales: Spidel, Jared L., Albone, Earl F., Cheng, Xin, Vaessen, Benjamin, Jacob, Sara, Milinichik, Andrew Z., Verdi, Arielle, Kline, J. Bradford, Grasso, Luigi
Formato: Artigo
Lenguaje:Inglês
Publicado: Taylor & Francis 2017
Materias:
Report
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5540084/
https://ncbi.nlm.nih.gov/pubmed/28541812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2017.1330734
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares