Generation of therapeutic immunoconjugates via Residue-Specific Conjugation Technology (RESPECT) utilizing a native cysteine in the light chain framework of Oryctolagus cuniculus

The conjugation of toxins, dyes, peptides, or proteins to monoclonal antibodies is often performed via free thiol groups generated by either partial reduction methods or engineering free cysteine residues into the antibody sequence. Antibodies from the rabbit Oryctolagus cuniculus have an additional...

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Detalhes bibliográficos
Publicado no:Cancer Biol Ther
Main Authors: Albone, Earl F., Spidel, Jared L., Cheng, Xin, Park, Young Chul, Jacob, Sara, Milinichik, Andrew Z., Vaessen, Ben, Butler, Janet, Kline, J. Bradford, Grasso, Luigi
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5499757/
https://ncbi.nlm.nih.gov/pubmed/28394698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2017.1312232
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