Generation of therapeutic immunoconjugates via Residue-Specific Conjugation Technology (RESPECT) utilizing a native cysteine in the light chain framework of Oryctolagus cuniculus

The conjugation of toxins, dyes, peptides, or proteins to monoclonal antibodies is often performed via free thiol groups generated by either partial reduction methods or engineering free cysteine residues into the antibody sequence. Antibodies from the rabbit Oryctolagus cuniculus have an additional...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Cancer Biol Ther
Prif Awduron: Albone, Earl F., Spidel, Jared L., Cheng, Xin, Park, Young Chul, Jacob, Sara, Milinichik, Andrew Z., Vaessen, Ben, Butler, Janet, Kline, J. Bradford, Grasso, Luigi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Taylor & Francis 2017
Pynciau:
Research Paper
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5499757/
https://ncbi.nlm.nih.gov/pubmed/28394698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2017.1312232
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