Engineering humanized antibody framework sequences for optimal site-specific conjugation of cytotoxins

The prevailing techniques used to generate antibody-drug conjugates (ADCs) involve random conjugation of the linker-drug to multiple lysines or cysteines in the antibody. Engineering natural and non-natural amino acids into an antibody has been demonstrated to be an effective strategy to produce hom...

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Détails bibliographiques
Publié dans:MAbs
Auteurs principaux: Spidel, Jared L., Albone, Earl F., Cheng, Xin, Vaessen, Benjamin, Jacob, Sara, Milinichik, Andrew Z., Verdi, Arielle, Kline, J. Bradford, Grasso, Luigi
Format: Artigo
Langue:Inglês
Publié: Taylor & Francis 2017
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5540084/
https://ncbi.nlm.nih.gov/pubmed/28541812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/19420862.2017.1330734
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