Molecular engineering of antibodies for site-specific covalent conjugation using CRISPR/Cas9

Site-specific modification of antibodies has become a critical aspect in the development of next-generation immunoconjugates meeting criteria of clinically acceptable homogeneity, reproducibility, efficacy, ease of manufacturability, and cost-effectiveness. Using CRISPR/Cas9 genomic editing, we deve...

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Publicado no:Sci Rep
Main Authors: Khoshnejad, Makan, Brenner, Jacob S., Motley, William, Parhiz, Hamideh, Greineder, Colin F., Villa, Carlos H., Marcos-Contreras, Oscar A., Tsourkas, Andrew, Muzykantov, Vladimir R.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5789018/
https://ncbi.nlm.nih.gov/pubmed/29379029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-19784-2
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