Generation of therapeutic immunoconjugates via Residue-Specific Conjugation Technology (RESPECT) utilizing a native cysteine in the light chain framework of Oryctolagus cuniculus

The conjugation of toxins, dyes, peptides, or proteins to monoclonal antibodies is often performed via free thiol groups generated by either partial reduction methods or engineering free cysteine residues into the antibody sequence. Antibodies from the rabbit Oryctolagus cuniculus have an additional...

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Detalles Bibliográficos
Publicado en:Cancer Biol Ther
Main Authors: Albone, Earl F., Spidel, Jared L., Cheng, Xin, Park, Young Chul, Jacob, Sara, Milinichik, Andrew Z., Vaessen, Ben, Butler, Janet, Kline, J. Bradford, Grasso, Luigi
Formato: Artigo
Idioma:Inglês
Publicado: Taylor & Francis 2017
Assuntos:
Research Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5499757/
https://ncbi.nlm.nih.gov/pubmed/28394698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384047.2017.1312232
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