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A Single Amino Acid Residue at Transmembrane Domain 4 of the α Subunit Influences Carisoprodol Direct Gating Efficacy at GABA(A) Receptors
The muscle relaxant carisoprodol has recently been controlled at the federal level as a Schedule IV drug due to its high abuse potential and consequences of misuse, such as withdrawal syndrome, delusions, seizures, and even death. Recent work has shown that carisoprodol can directly gate and alloste...
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| 發表在: | J Pharmacol Exp Ther |
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| Main Authors: | , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
The American Society for Pharmacology and Experimental Therapeutics
2017
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5539590/ https://ncbi.nlm.nih.gov/pubmed/28642232 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.117.242156 |
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