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The differentiation of ROR-γt expressing iNKT17 cells is orchestrated by Runx1
iNKT cells are a unique lineage of T cells that recognize glycolipid presented by CD1d. In the thymus, they differentiate into iNKT1, iNKT2 and iNKT17 effector subsets, characterized by preferential expression of Tbet, Gata3 and ROR-γt and production of IFN-γ, IL-4 and IL-17, respectively. We demons...
Shranjeno v:
| izdano v: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group UK
2017
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5539328/ https://ncbi.nlm.nih.gov/pubmed/28765611 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-07365-8 |
| Oznake: |
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