Exosomes Facilitate Therapeutic Targeting of Oncogenic Kras in Pancreatic Cancer

The mutant form of the GTPase KRAS is a key driver of pancreatic cancer but remains a challenging therapeutic target. Exosomes, extracellular vesicles generated by all cells, are naturally present in the blood. Here we demonstrate that enhanced retention of exosomes in circulation, compared to lipos...

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Udgivet i:Nature
Main Authors: Kamerkar, Sushrut, LeBleu, Valerie S., Sugimoto, Hikaru, Yang, Sujuan, Ruivo, Carolina F., Melo, Sonia A., Lee, J. Jack, Kalluri, Raghu
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5538883/
https://ncbi.nlm.nih.gov/pubmed/28607485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature22341
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