Desmin loss and mitochondrial damage precede left ventricular systolic failure in volume overload heart failure

Heart failure due to chronic volume overload (VO) in rats and humans is characterized by disorganization of the cardiomyocyte desmin/mitochondrial network. Here, we tested the hypothesis that desmin breakdown is an early and continuous process throughout VO. Male Sprague-Dawley rats had aortocaval f...

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Vydáno v:Am J Physiol Heart Circ Physiol
Hlavní autoři: Guichard, Jason L., Rogowski, Michael, Agnetti, Giulio, Fu, Lianwu, Powell, Pamela, Wei, Chih-Chang, Collawn, James, Dell’Italia, Louis J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Physiological Society 2017
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5538858/
https://ncbi.nlm.nih.gov/pubmed/28455287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00027.2017
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