Desmin loss and mitochondrial damage precede left ventricular systolic failure in volume overload heart failure

Heart failure due to chronic volume overload (VO) in rats and humans is characterized by disorganization of the cardiomyocyte desmin/mitochondrial network. Here, we tested the hypothesis that desmin breakdown is an early and continuous process throughout VO. Male Sprague-Dawley rats had aortocaval f...

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Detalhes bibliográficos
Publicado no:Am J Physiol Heart Circ Physiol
Main Authors: Guichard, Jason L., Rogowski, Michael, Agnetti, Giulio, Fu, Lianwu, Powell, Pamela, Wei, Chih-Chang, Collawn, James, Dell’Italia, Louis J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5538858/
https://ncbi.nlm.nih.gov/pubmed/28455287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00027.2017
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