Increased fibroblast chymase production mediates procollagen autophagic digestion in volume overload

BACKGROUND: Previous work has identified mast cells as the major source of chymase largely associated with a profibrotic phenotype. We recently reported increased fibroblast autophagic procollagen degradation in a rat model of pure volume overload (VO). Here we demonstrate a connection between incre...

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Bibliographic Details
Published in:J Mol Cell Cardiol
Main Authors: Fu, Lianwu, Wei, Chih-Chang, Powell, Pamela C., Bradley, Wayne E., Ahmad, Sarfaraz, Ferrario, Carlos M., Collawn, James F., Dell’Italia, Louis J.
Format: Artigo
Language:Inglês
Published: 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5198899/
https://ncbi.nlm.nih.gov/pubmed/26807691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2016.01.019
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