Cardiac Kallikrein-Kinin System Is Upregulated in Chronic Volume Overload and Mediates an Inflammatory Induced Collagen Loss

BACKGROUND: The clinical problem of a “pure volume overload” as in isolated mitral or aortic regurgitation currently has no documented medical therapy that attenuates collagen loss and the resultant left ventricular (LV) dilatation and failure. Here, we identify a potential mechanism related to upre...

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Detalhes bibliográficos
Main Authors: Wei, Chih-Chang, Chen, Yuanwen, Powell, Lindsay C., Zheng, Junying, Shi, Ke, Bradley, Wayne E., Powell, Pamela C., Ahmad, Sarfaraz, Ferrario, Carlos M., Dell’Italia, Louis J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3387019/
https://ncbi.nlm.nih.gov/pubmed/22768235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0040110
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