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Volume overload induces autophagic degradation of procollagen in cardiac fibroblasts
In a pure volume overloaded (VO) heart, interstitial collagen loss is degraded by matrix metalloproteinases (MMPs) that leads to left ventricular (LV) dilatation and heart failure. Cardiac fibroblasts are the primary source of extracellular matrix proteins that connect cardiomyocytes. The goal of th...
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| Publicado no: | J Mol Cell Cardiol |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4689667/ https://ncbi.nlm.nih.gov/pubmed/26596413 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yjmcc.2015.10.027 |
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