Xanthine oxidase inhibition preserves left ventricular systolic but not diastolic function in cardiac volume overload

Xanthine oxidase (XO) is increased in human and rat left ventricular (LV) myocytes with volume overload (VO) of mitral regurgitation and aortocaval fistula (ACF). In the setting of increased ATP demand, XO-mediated ROS can decrease mitochondrial respiration and contractile function. Thus, we tested...

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Bibliografski detalji
Glavni autori: Gladden, James D., Zelickson, Blake R., Guichard, Jason L., Ahmed, Mustafa I., Yancey, Danielle M., Ballinger, Scott, Shanmugam, Mayilvahanan, Babu, Gopal J., Johnson, Michelle S., Darley-Usmar, Victor, Dell'Italia, Louis J.
Format: Artigo
Jezik:Inglês
Izdano: American Physiological Society 2013
Teme:
Call for Papers
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4073978/
https://ncbi.nlm.nih.gov/pubmed/24014679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00007.2013
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