Xanthine oxidase inhibition preserves left ventricular systolic but not diastolic function in cardiac volume overload

Xanthine oxidase (XO) is increased in human and rat left ventricular (LV) myocytes with volume overload (VO) of mitral regurgitation and aortocaval fistula (ACF). In the setting of increased ATP demand, XO-mediated ROS can decrease mitochondrial respiration and contractile function. Thus, we tested...

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Hauptverfasser: Gladden, James D., Zelickson, Blake R., Guichard, Jason L., Ahmed, Mustafa I., Yancey, Danielle M., Ballinger, Scott, Shanmugam, Mayilvahanan, Babu, Gopal J., Johnson, Michelle S., Darley-Usmar, Victor, Dell'Italia, Louis J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2013
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4073978/
https://ncbi.nlm.nih.gov/pubmed/24014679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00007.2013
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