Xanthine oxidase inhibition preserves left ventricular systolic but not diastolic function in cardiac volume overload

Xanthine oxidase (XO) is increased in human and rat left ventricular (LV) myocytes with volume overload (VO) of mitral regurgitation and aortocaval fistula (ACF). In the setting of increased ATP demand, XO-mediated ROS can decrease mitochondrial respiration and contractile function. Thus, we tested...

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Detaylı Bibliyografya
Asıl Yazarlar: Gladden, James D., Zelickson, Blake R., Guichard, Jason L., Ahmed, Mustafa I., Yancey, Danielle M., Ballinger, Scott, Shanmugam, Mayilvahanan, Babu, Gopal J., Johnson, Michelle S., Darley-Usmar, Victor, Dell'Italia, Louis J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Physiological Society 2013
Konular:
Call for Papers
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4073978/
https://ncbi.nlm.nih.gov/pubmed/24014679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00007.2013
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