Xanthine oxidase inhibition preserves left ventricular systolic but not diastolic function in cardiac volume overload

Xanthine oxidase (XO) is increased in human and rat left ventricular (LV) myocytes with volume overload (VO) of mitral regurgitation and aortocaval fistula (ACF). In the setting of increased ATP demand, XO-mediated ROS can decrease mitochondrial respiration and contractile function. Thus, we tested...

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Main Authors: Gladden, James D., Zelickson, Blake R., Guichard, Jason L., Ahmed, Mustafa I., Yancey, Danielle M., Ballinger, Scott, Shanmugam, Mayilvahanan, Babu, Gopal J., Johnson, Michelle S., Darley-Usmar, Victor, Dell'Italia, Louis J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2013
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Call for Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4073978/
https://ncbi.nlm.nih.gov/pubmed/24014679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00007.2013
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