Xanthine oxidase inhibition preserves left ventricular systolic but not diastolic function in cardiac volume overload

Xanthine oxidase (XO) is increased in human and rat left ventricular (LV) myocytes with volume overload (VO) of mitral regurgitation and aortocaval fistula (ACF). In the setting of increased ATP demand, XO-mediated ROS can decrease mitochondrial respiration and contractile function. Thus, we tested...

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Главные авторы: Gladden, James D., Zelickson, Blake R., Guichard, Jason L., Ahmed, Mustafa I., Yancey, Danielle M., Ballinger, Scott, Shanmugam, Mayilvahanan, Babu, Gopal J., Johnson, Michelle S., Darley-Usmar, Victor, Dell'Italia, Louis J.
Формат: Artigo
Язык:Inglês
Опубликовано: American Physiological Society 2013
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4073978/
https://ncbi.nlm.nih.gov/pubmed/24014679
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpheart.00007.2013
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