Quantification of the impact of the HIV-1-glycan shield on antibody elicitation

While the HIV-1-glycan shield is known to shelter Env from the humoral immune response, its quantitative impact on antibody elicitation has been unclear. Here we use targeted deglycosylation to measure the impact of the glycan shield on elicitation of antibodies against the CD4 supersite. We enginee...

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Publicado no:Cell Rep
Main Authors: Zhou, Tongqing, Doria-Rose, Nicole A., Cheng, Cheng, Stewart-Jones, Guillaume B.E., Chuang, Gwo-Yu, Chambers, Michael, Druz, Aliaksandr, Geng, Hui, McKee, Krisha, Kwon, Young D., O’Dell, Sijy, Sastry, Mallika, Schmidt, Stephen D., Xu, Kai, Chen, Lei, Chen, Rita E., Louder, Mark K., Pancera, Marie, Wanninger, Timothy G., Zhang, Baoshan, Zheng, Anqi, Farney, S. Katie, Foulds, Kathryn E., Georgiev, Ivelin S., Joyce, M. Gordon, Lemmin, Thomas, Narpala, Sandeep, Rawi, Reda, Soto, Cinque, Todd, John-Paul, Shen, Chen-Hsiang, Tsybovsky, Yaroslav, Yang, Yongping, Zhao, Peng, Haynes, Barton F., Stamatatos, Leonidas, Tiemeyer, Michael, Wells, Lance, Scorpio, Diana G., Shapiro, Lawrence, McDermott, Adrian B., Mascola, John R., Kwong, Peter D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5538809/
https://ncbi.nlm.nih.gov/pubmed/28445724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.04.013
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