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Inhibitory effects and mechanism of dihydroberberine on hERG channels expressed in HEK293 cells

The human ether-a-go-go-related gene (hERG) potassium channel conducts rapid delayed rectifier potassium currents (I(Kr)) and contributes to phase III cardiac action potential repolarization. Drugs inhibit hERG channels by binding to aromatic residues in hERG helixes. Berberine (BBR) has multiple ac...

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Bibliografische gegevens
Gepubliceerd in:PLoS One
Hoofdauteurs: Yu, Dahai, Lv, Lin, Fang, Li, Zhang, Bo, Wang, Junnan, Zhan, Ge, Zhao, Lei, Zhao, Xin, Li, Baoxin
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5538702/
https://ncbi.nlm.nih.gov/pubmed/28763460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0181823
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