Inhibitory effects and mechanism of dihydroberberine on hERG channels expressed in HEK293 cells

The human ether-a-go-go-related gene (hERG) potassium channel conducts rapid delayed rectifier potassium currents (I(Kr)) and contributes to phase III cardiac action potential repolarization. Drugs inhibit hERG channels by binding to aromatic residues in hERG helixes. Berberine (BBR) has multiple ac...

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Foilsithe in:PLoS One
Main Authors: Yu, Dahai, Lv, Lin, Fang, Li, Zhang, Bo, Wang, Junnan, Zhan, Ge, Zhao, Lei, Zhao, Xin, Li, Baoxin
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2017
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5538702/
https://ncbi.nlm.nih.gov/pubmed/28763460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0181823
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