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Principles of Reconstructing the Subclonal Architecture of Cancers

Most cancers evolve from a single founder cell through a series of clonal expansions that are driven by somatic mutations. These clonal expansions can lead to several coexisting subclones sharing subsets of mutations. Analysis of massively parallel sequencing data can infer a tumor’s subclonal compo...

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Vydáno v:Cold Spring Harb Perspect Med
Hlavní autoři: Dentro, Stefan C., Wedge, David C., Van Loo, Peter
Médium: Artigo
Jazyk:Inglês
Vydáno: Cold Spring Harbor Laboratory Press 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5538405/
https://ncbi.nlm.nih.gov/pubmed/28270531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/cshperspect.a026625
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