Tracking the origins and drivers of subclonal metastatic expansion in prostate cancer

Tumour heterogeneity in primary prostate cancer is a well-established phenomenon. However, how the subclonal diversity of tumours changes during metastasis and progression to lethality is poorly understood. Here we reveal the precise direction of metastatic spread across four lethal prostate cancer...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Hong, Matthew K.H., Macintyre, Geoff, Wedge, David C., Van Loo, Peter, Patel, Keval, Lunke, Sebastian, Alexandrov, Ludmil B., Sloggett, Clare, Cmero, Marek, Marass, Francesco, Tsui, Dana, Mangiola, Stefano, Lonie, Andrew, Naeem, Haroon, Sapre, Nikhil, Phal, Pramit M., Kurganovs, Natalie, Chin, Xiaowen, Kerger, Michael, Warren, Anne Y., Neal, David, Gnanapragasam, Vincent, Rosenfeld, Nitzan, Pedersen, John S., Ryan, Andrew, Haviv, Izhak, Costello, Anthony J., Corcoran, Niall M., Hovens, Christopher M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4396364/
https://ncbi.nlm.nih.gov/pubmed/25827447
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7605
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