Reducing mitochondrial bound hexokinase II mediates transition from non-injurious into injurious ischemia/reperfusion of the intact heart

Ischemia/reperfusion (I/R) of the heart becomes injurious when duration of the ischemic insult exceeds a certain threshold (approximately ≥20 min). Mitochondrial bound hexokinase II (mtHKII) protects against I/R injury, with the amount of mtHKII correlating with injury. Here, we examine whether mtHK...

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Publicat a:J Physiol Biochem
Autors principals: Nederlof, Rianne, Gürel-Gurevin, Ebru, Eerbeek, Otto, Xie, Chaoqin, Deijs, G. Sjoerd, Konkel, Moritz, Hu, Jun, Weber, Nina C., Schumacher, Cees A., Baartscheer, Antonius, Mik, Egbert G., Hollmann, Markus W., Akar, Fadi G., Zuurbier, Coert J.
Format: Artigo
Idioma:Inglês
Publicat: Springer Netherlands 2017
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5534207/
https://ncbi.nlm.nih.gov/pubmed/28258543
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s13105-017-0555-3
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