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Methods of probing the interactions between small molecules and disordered proteins

It is generally recognized that a large fraction of the human proteome is made up of proteins that remain disordered in their native states. Despite the fact that such proteins play key biological roles and are involved in many major human diseases, they still represent challenging targets for drug...

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Bibliografische gegevens
Gepubliceerd in:Cell Mol Life Sci
Hoofdauteurs: Heller, Gabriella T., Aprile, Francesco A., Vendruscolo, Michele
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Springer International Publishing 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5533867/
https://ncbi.nlm.nih.gov/pubmed/28631009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-017-2563-4
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