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Methods of probing the interactions between small molecules and disordered proteins

It is generally recognized that a large fraction of the human proteome is made up of proteins that remain disordered in their native states. Despite the fact that such proteins play key biological roles and are involved in many major human diseases, they still represent challenging targets for drug...

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Detalhes bibliográficos
Publicado no:Cell Mol Life Sci
Main Authors: Heller, Gabriella T., Aprile, Francesco A., Vendruscolo, Michele
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5533867/
https://ncbi.nlm.nih.gov/pubmed/28631009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00018-017-2563-4
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