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Deciphering the regulation of P2X4 receptor channel gating by ivermectin using Markov models

The P2X4 receptor (P2X4R) is a member of a family of purinergic channels activated by extracellular ATP through three orthosteric binding sites and allosterically regulated by ivermectin (IVM), a broad-spectrum antiparasitic agent. Treatment with IVM increases the efficacy of ATP to activate P2X4R,...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Mackay, Laurent, Zemkova, Hana, Stojilkovic, Stanko S., Sherman, Arthur, Khadra, Anmar
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5533465/
https://ncbi.nlm.nih.gov/pubmed/28708827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005643
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