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Deciphering the regulation of P2X4 receptor channel gating by ivermectin using Markov models
The P2X4 receptor (P2X4R) is a member of a family of purinergic channels activated by extracellular ATP through three orthosteric binding sites and allosterically regulated by ivermectin (IVM), a broad-spectrum antiparasitic agent. Treatment with IVM increases the efficacy of ATP to activate P2X4R,...
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Publicado no: | PLoS Comput Biol |
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Main Authors: | , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Public Library of Science
2017
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5533465/ https://ncbi.nlm.nih.gov/pubmed/28708827 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005643 |
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