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Experimental Characterization and Mathematical Modeling of P2X7 Receptor Channel Gating

The P2X7 receptor is a trimeric channel with three binding sites for ATP, but how the occupancy of these sites affects gating is still not understood. Here we show that naive receptors activated and deactivated monophasically at low and biphasically at higher agonist concentrations. Both phases of r...

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Библиографические подробности
Главные авторы: Yan, Zonghe, Khadra, Anmar, Li, Shuo, Tomić, Melanija, Sherman, Arthur, Stojilkovic, Stanko S.
Формат: Artigo
Язык:Inglês
Опубликовано: Society for Neuroscience 2010
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2980950/
https://ncbi.nlm.nih.gov/pubmed/20962242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2390-10.2010
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