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Warfarin traps human vitamin K epoxide reductase in an intermediate state during electron transfer
Although warfarin is the most widely used anticoagulant worldwide, the mechanism by which warfarin inhibits its target, human vitamin K epoxide reductase (hVKOR), remains unclear. Here we show that warfarin blocks a dynamic electron-transfer process in hVKOR. A major fraction of cellular hVKOR is at...
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| Vydáno v: | Nat Struct Mol Biol |
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| Hlavní autoři: | , , , , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2016
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5533293/ https://ncbi.nlm.nih.gov/pubmed/27918545 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3333 |
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