Warfarin traps human vitamin K epoxide reductase in an intermediate state during electron transfer

Although warfarin is the most widely used anticoagulant worldwide, the mechanism by which warfarin inhibits its target, human vitamin K epoxide reductase (hVKOR), remains unclear. Here we show that warfarin blocks a dynamic electron-transfer process in hVKOR. A major fraction of cellular hVKOR is at...

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Detalhes bibliográficos
Publicado no:Nat Struct Mol Biol
Main Authors: Shen, Guomin, Cui, Weidong, Zhang, Hao, Zhou, Fengbo, Huang, Wei, Liu, Qian, Yang, Yihu, Li, Shuang, Bowman, Gregory R., Sadler, J. Evan, Gross, Michael L., Li, Weikai
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5533293/
https://ncbi.nlm.nih.gov/pubmed/27918545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.3333
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