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Structures of an intramembrane vitamin K epoxide reductase homolog reveal control mechanisms for electron transfer
The intramembrane vitamin K epoxide reductase (VKOR) supports blood coagulation in humans and is the target of the anticoagulant warfarin. VKOR and its homologs generate disulfide bonds in organisms ranging from bacteria to humans. Here, to better understand the mechanism of VKOR catalysis, we repor...
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| Veröffentlicht in: | Nat Commun |
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| Hauptverfasser: | , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2014
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4360977/ https://ncbi.nlm.nih.gov/pubmed/24477003 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4110 |
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