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RSPO3 expands intestinal stem cell and niche compartments and drives tumorigenesis
OBJECTIVE: The gross majority of colorectal cancer cases results from aberrant Wnt/β-catenin signalling through adenomatous polyposis coli (APC) or CTNNB1 mutations. However, a subset of human colon tumours harbour, mutually exclusive with APC and CTNNB1 mutations, gene fusions in RSPO2 or RSPO3, le...
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| Pubblicato in: | Gut |
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| Autori principali: | , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BMJ Publishing Group
2017
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5532462/ https://ncbi.nlm.nih.gov/pubmed/27511199 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2016-311606 |
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