HMGA1 amplifies Wnt signalling and expands the intestinal stem cell compartment and Paneth cell niche

High-mobility group A1 (Hmga1) chromatin remodelling proteins are enriched in intestinal stem cells (ISCs), although their function in this setting was unknown. Prior studies showed that Hmga1 drives hyperproliferation, aberrant crypt formation and polyposis in transgenic mice. Here we demonstrate t...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Xian, Lingling, Georgess, Dan, Huso, Tait, Cope, Leslie, Belton, Amy, Chang, Yu-Ting, Kuang, Wenyong, Gu, Qihua, Zhang, Xiaoyan, Senger, Stefania, Fasano, Alessio, Huso, David L., Ewald, Andrew J., Resar, Linda M. S.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5414379/
https://ncbi.nlm.nih.gov/pubmed/28452345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15008
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