RSPO3 expands intestinal stem cell and niche compartments and drives tumorigenesis

OBJECTIVE: The gross majority of colorectal cancer cases results from aberrant Wnt/β-catenin signalling through adenomatous polyposis coli (APC) or CTNNB1 mutations. However, a subset of human colon tumours harbour, mutually exclusive with APC and CTNNB1 mutations, gene fusions in RSPO2 or RSPO3, le...

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Detalles Bibliográficos
Publicado en:Gut
Main Authors: Hilkens, John, Timmer, Nikki C, Boer, Mandy, Ikink, Gerjon J, Schewe, Matthias, Sacchetti, Andrea, Koppens, Martijn A J, Song, Ji-Ying, Bakker, Elvira R M
Formato: Artigo
Idioma:Inglês
Publicado: BMJ Publishing Group 2017
Assuntos:
GI cancer
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5532462/
https://ncbi.nlm.nih.gov/pubmed/27511199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/gutjnl-2016-311606
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