Recent translational research: Oncogene discovery by insertional mutagenesis gets a new boost

Por Hilkens, John
Publicado em 2006

Insulin receptor substrate 4 (IRS4) is a constitutive active oncogenic driver collaborating with HER2 and causing therapeutic resistance

Por Ikink, Gerjon J., Hilkens, John
Publicado no Mol Cell Oncol (2017)

AsialoGM1 and integrin α2β1 mediate prostate cancer progression

Por Van Slambrouck, Severine, Hilkens, John, Bisoffi, Marco, Steelant, Wim F.A.
Publicado em 2009

IRS4 induces mammary tumorigenesis and confers resistance to HER2-targeted therapy through constitutive PI3K/AKT-pathway hyperactivation

Por Ikink, Gerjon J., Boer, Mandy, Bakker, Elvira R. M., Hilkens, John
Publicado no Nat Commun (2016)

Interaction between circulating galectin-3 and cancer-associated MUC1 enhances tumour cell homotypic aggregation and prevents anoikis

Por Zhao, Qicheng, Barclay, Monica, Hilkens, John, Guo, Xiuli, Barrow, Hannah, Rhodes, Jonathan M, Yu, Lu-Gang
Publicado em 2010

Circulating galectin-3 promotes metastasis by modifying MUC1 localization on cancer cell surface

Por Zhao, Qicheng, Guo, Xiuli, Nash, Gerard B., Stone, Philip C., Hilkens, John, Rhodes, Jonathan M., Yu, Lu-Gang
Publicado em 2009

RSPO3 expands intestinal stem cell and niche compartments and drives tumorigenesis

Por Hilkens, John, Timmer, Nikki C, Boer, Mandy, Ikink, Gerjon J, Schewe, Matthias, Sacchetti, Andrea, Koppens, Martijn A J, Song, Ji-Ying, Bakker, Elvira R M
Publicado no Gut (2017)

Chromatin Landscapes of Retroviral and Transposon Integration Profiles

Por de Jong, Johann, Akhtar, Waseem, Badhai, Jitendra, Rust, Alistair G., Rad, Roland, Hilkens, John, Berns, Anton, van Lohuizen, Maarten, Wessels, Lodewyk F. A., de Ridder, Jeroen
Publicado em 2014

MUC1-ARF—A Novel MUC1 Protein That Resides in the Nucleus and Is Expressed by Alternate Reading Frame Translation of MUC1 mRNA

Por Chalick, Michael, Jacobi, Oded, Pichinuk, Edward, Garbar, Christian, Bensussan, Armand, Meeker, Alan, Ziv, Ravit, Zehavi, Tania, Smorodinsky, Nechama I., Hilkens, John, Hanisch, Franz-Georg, Rubinstein, Daniel B., Wreschner, Daniel H.
Publicado no PLoS One (2016)

Analysis of Tumor Heterogeneity and Cancer Gene Networks Using Deep Sequencing of MMTV-Induced Mouse Mammary Tumors

Por Klijn, Christiaan, Koudijs, Marco J., Kool, Jaap, ten Hoeve, Jelle, Boer, Mandy, de Moes, Joost, Akhtar, Waseem, van Miltenburg, Martine, Vendel-Zwaagstra, Annabel, Reinders, Marcel J. T., Adams, David J., van Lohuizen, Maarten, Hilkens, John, Wessels, Lodewyk F. A., Jonkers, Jos
Publicado em 2013