Architecture of the human interactome defines protein communities and disease networks

The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transd...

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Veröffentlicht in:Nature
Hauptverfasser: Huttlin, Edward L., Bruckner, Raphael J., Paulo, Joao A., Cannon, Joe R., Ting, Lily, Baltier, Kurt, Colby, Greg, Gebreab, Fana, Gygi, Melanie P., Parzen, Hannah, Szpyt, John, Tam, Stanley, Zarraga, Gabriela, Pontano-Vaites, Laura, Swarup, Sharan, White, Anne E., Schweppe, Devin K., Rad, Ramin, Erickson, Brian K., Obar, Robert A., Guruharsha, K.G., Li, Kejie, Artavanis-Tsakonas, Spyros, Gygi, Steven P., Harper, J. Wade
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5531611/
https://ncbi.nlm.nih.gov/pubmed/28514442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature22366
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