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The Notch signalling system: recent insights into the complexity of a conserved pathway

Notch signalling links the fate of one cell to that of an immediate neighbour and consequently controls differentiation, proliferation and apoptotic events in multiple metazoan tissues. Perturbations in this pathway activity have been linked to several human genetic disorders and cancers. Recent gen...

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Detalhes bibliográficos
Publicado no:Nat Rev Genet
Main Authors: Guruharsha, K. G., Kankel, Mark W., Artavanis-Tsakonas, Spyros
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4369923/
https://ncbi.nlm.nih.gov/pubmed/22868267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrg3272
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