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Carborane-based design of a potent vitamin D receptor agonist

The vitamin D nuclear receptor (VDR) is a potential target for cancer therapy. It is expressed in many tumors and its ligand shows anticancer actions. To combine these properties with the application of boron neutron capture therapy (BNCT), we design and synthesize a potent VDR agonist based on the...

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Bibliografiske detaljer
Udgivet i:Chem Sci
Main Authors: Otero, Rocio, Seoane, Samuel, Sigüeiro, Rita, Belorusova, Anna Y., Maestro, Miguel A., Pérez-Fernández, Roman, Rochel, Natacha, Mouriño, Antonio
Format: Artigo
Sprog:Inglês
Udgivet: Royal Society of Chemistry 2016
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5531031/
https://ncbi.nlm.nih.gov/pubmed/28808527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c5sc03084f
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