Pit-1 inhibits BRCA1 and sensitizes human breast tumors to cisplatin and vitamin D treatment

The POU class 1 homeobox 1 (POU1F1, also known as Pit-1), pertaining to the Pit-Oct-Unc (POU) family of transcription factors, has been related to tumor growth and metastasis in breast. However, its role in response to breast cancer therapy is unknown. We found that Pit-1 down-regulated DNA-damage a...

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Bibliografiska uppgifter
I publikationen:Oncotarget
Huvudupphovsmän: Seoane, Samuel, Arias, Efigenia, Sigueiro, Rita, Sendon-Lago, Juan, Martinez-Ordoñez, Anxo, Castelao, Esteban, Eiró, Noemí, Garcia-Caballero, Tomás, Macia, Manuel, Lopez-Lopez, Rafael, Maestro, Miguel, Vizoso, Francisco, Mouriño, Antonio, Perez-Fernandez, Roman
Materialtyp: Artigo
Språk:Inglês
Publicerad: Impact Journals LLC 2015
Ämnen:
Research Paper
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4546479/
https://ncbi.nlm.nih.gov/pubmed/25992773
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