Pit-1 inhibits BRCA1 and sensitizes human breast tumors to cisplatin and vitamin D treatment

The POU class 1 homeobox 1 (POU1F1, also known as Pit-1), pertaining to the Pit-Oct-Unc (POU) family of transcription factors, has been related to tumor growth and metastasis in breast. However, its role in response to breast cancer therapy is unknown. We found that Pit-1 down-regulated DNA-damage a...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Seoane, Samuel, Arias, Efigenia, Sigueiro, Rita, Sendon-Lago, Juan, Martinez-Ordoñez, Anxo, Castelao, Esteban, Eiró, Noemí, Garcia-Caballero, Tomás, Macia, Manuel, Lopez-Lopez, Rafael, Maestro, Miguel, Vizoso, Francisco, Mouriño, Antonio, Perez-Fernandez, Roman
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2015
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4546479/
https://ncbi.nlm.nih.gov/pubmed/25992773
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