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Hidden electrostatic basis of dynamic allostery in a PDZ domain
Allosteric effect implies ligand binding at one site leading to structural and/or dynamical changes at a distant site. PDZ domains are classic examples of dynamic allostery without conformational changes, where distal side-chain dynamics is modulated on ligand binding and the origin has been attribu...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5530692/ https://ncbi.nlm.nih.gov/pubmed/28634294 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1705311114 |
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