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Intramembrane aspartic acid in SCAP protein governs cholesterol-induced conformational change
The polytopic membrane protein SCAP transports sterol regulatory element-binding proteins (SREBPs) from the endoplasmic reticulum (ER) to the Golgi, thereby activating cholesterol synthesis. Cholesterol accumulation in the ER membranes changes SCAP to an alternate conformation in which it binds ER r...
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| Publicado no: | Proc Natl Acad Sci U S A |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC552931/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15728349/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.0500206102 |
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