Intramembrane aspartic acid in SCAP protein governs cholesterol-induced conformational change

The polytopic membrane protein SCAP transports sterol regulatory element-binding proteins (SREBPs) from the endoplasmic reticulum (ER) to the Golgi, thereby activating cholesterol synthesis. Cholesterol accumulation in the ER membranes changes SCAP to an alternate conformation in which it binds ER r...

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Bibliographic Details
Main Authors: Feramisco, Jamison D., Radhakrishnan, Arun, Ikeda, Yukio, Reitz, Julian, Brown, Michael S., Goldstein, Joseph L.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2005
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC552931/
https://ncbi.nlm.nih.gov/pubmed/15728349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0500206102
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