Ubiquitin specific protease 4 positively regulates the WNT/β‐catenin signaling in colorectal cancer

β‐catenin is a key signal transducer in the canonical WNT pathway and is negatively regulated by ubiquitin‐dependent proteolysis. Through screening of various deubiquitinating enzymes (DUBs), we identified ubiquitin specific protease 4 (USP4) as a candidate for β‐catenin‐specific DUB. The effects of...

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Détails bibliographiques
Publié dans:Mol Oncol
Auteurs principaux: Yun, Sun-Il, Kim, Hyeon Ho, Yoon, Jung Hwan, Park, Won Sang, Hahn, Myong-Joon, Kim, Hee Cheol, Chung, Chin Ha, Kim, Kyeong Kyu
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2015
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528720/
https://ncbi.nlm.nih.gov/pubmed/26189775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2015.06.006
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